ajpheart.physiology.orgAmerican Journal of Physiology-Heart and Circulatory Physiology

Login to your account Institutional Login Sign In / Register PHYSIOLOGY.ORGClose Drawer Menu Open Drawer Menu Home Journals AJP-Cell AJP-Endo AJP-GI AJP-Heart AJP-Lung AJP-Regu AJP-Renal AJP (1898-1976) Function J Appl Physiol J Neurophysiol Physiol Genomics Adv Physiol Educ Physiology Physiol Rev PHYSIOL REP COMPR PHYSIOL APSselect All journals This Journal Quick Search anywhere Search all content Search Advanced Search Quick Search in Journals Search all content Search Advanced Search Advanced Search 0 Sign inClose Drawer Menu Open Drawer Menu Home COLLECTIONS COVID-19 Cross-Journal AJP-CELL AJP-ENDO AJP-GI AJP-HEART AJP-REGU JAPPL JN PG ADVANCES APS LEGACY APSSELECT This Month’s Selections About INFORMATION For Authors For Reviewers For Librarians For Advertisers For Media/Public For APS Members OTHER PUBLICATIONS Books The Physiologist Magazine ABOUT APS Publications American Physiological Society SUBMIT SUBSCRIBE HELPHome Issues Collections Information About Editor-in-Chief Irving H. Zucker Information for Authors TOC alerts RSS Feed Twitter Facebook LinkedIn Current issue July 2020; volume 319, issue 1 EDITORIAL Integrative Cardiovascular Physiology and Pathophysiology Is Teamwork Still Possible during a Global Pandemic? Irving H. Zucker 2020 Jun 10 : H1-H2 https://doi.org/10.1152/ajpheart.00408.2020 RESEARCH ARTICLES Cardiovascular Neurohormonal Regulation Chemogenetic activation of intracardiac cholinergic neurons improves cardiac function in pressure overload-induced heart failure Jhansi Dyavanapalli, Aloysius James Hora, Joan B. Escobar, John Schloen, Mary Kate Dwyer, Jeannette Rodriguez, Christopher F. Spurney, Matthew W. Kay, David Mendelowitz 2020 Jun 10 : H3-H12 https://doi.org/10.1152/ajpheart.00150.2020 Intracardiac ganglia form the final common pathway for the parasympathetic innervation of the heart. This study has used a novel chemogenetic approach within transgenic ChAT-Cre rats [expressing only Cre-recombinase in choline acetyl transferase (ChAT) neurons] to selectively increase intracardiac cholinergic parasympathetic activity to the heart in a pressure overload-induced heart failure model. The findings from this study confirm that selective activation of intracardiac cholinergic neurons lessens cardiac dysfunction and mortality seen in heart failure, identifying a novel downstream cardiac-selective target for increasing cardioprotective parasympathetic activity in heart failure. Exercise and Cardiac Remodeling in Normal and Athletic States Cardiac endurance training alters plasma profiles of circular RNA MBOAT2 Anna Meinecke, Saskia Mitzka, Annette Just, Sarah Cushman, Stevan D. Stojanović, Ke Xiao, Frank C. Mooren, Jan Fiedler, Thomas Thum 2020 Jun 10 : H13-H21 https://doi.org/10.1152/ajpheart.00067.2020 In brief, we herein report a timeline of circulating circular RNA (circRNA) MBOAT2 in a cohort of marathon runners. Time-course analysis of plasmatic circRNA MBOAT2 demonstrated a significantly lowered level 24 h after the marathon. Abundancy of circRNA was correlated to physical exercise parameters highlighting the role of circRNA MBOAT2 as a valuable noncoding RNA biomarker detecting and following up cardiopulmonary adaption. Integrative Cardiovascular Physiology and Pathophysiology Neurovascular coupling is not influenced by lower body negative pressure in humans Milena Samora, Lauro C. Vianna, Jake C. Carmo, Victor Macedo, Matthew Dawes, Aaron A. Phillips, Julian F. R. Paton, James P. Fisher 2020 Jun 10 : H22-H31 https://doi.org/10.1152/ajpheart.00076.2020 Visual stimulation evoked a robust increase in posterior cerebral artery velocity and a modest increase in vertebral artery blood flow, i.e., neurovascular coupling (NVC), which was unaffected by lower body negative pressure in humans (LBNP). In addition, although LBNP induced a mild hypocapnia, this degree of hypocapnia in the absence of LBNP failed to modify the NVC response. See full Table of Contents Editor-in-Chief Irving H. Zucker Calls for Papers Information for Authors TOC alerts RSS Feed Twitter Facebook LinkedIn From the Editor’s Desk Skip slideshow Take a tour of the June 2020 issue of AJP-Heart and Circulatory Physiology in this episode of "From the Editor’s Desk" hosted by Editor-in-Chief Dr. Irv Zucker. Enjoy! Podcasts Skip slideshow Smoking Effects on Ventricular Repolarization - We know that smoking increases the risk of sudden cardiac death, which is linked to changes in ventricular repolarization. Is there a difference in sudden cardiac death risk between smoking tobacco cigarettes vs. e-cigarettes? Associate Editor Nisha Charkoudian (U.S. Army Research Institute for Environmental Medicine) interviews lead author Holly Middlekauff (University of California Los Angeles) and content expert Marmar Vaseghi (University of California Los Angeles) about the new study by Ip et al. [ More ] Read the article: 10.1152/ajpheart.00738.2019 PTSD and Sympathetic Action Potential Discharge Pattern - Women develop post-traumatic stress disorder (PTSD) at twice the rate of men, and women with PTSD are at higher risk for developing hypertension. Yet little research has been done to date investigating the mechanisms mediating the link between PTSD and cardiovascular disease in women. The study by Yoo et al. seeks to change that. — Jeung-Ki Yoo, Mark B. Badrov, Mu Huang, Ryan A. Bain, Raymond P. Dorn, Elizabeth H. Anderson, Jessica L. Wiblin, Alina Suris, J. Kevin Shoemaker, Qi Fu. [ More ] Read the article: 10.1152/ajpheart.00684.2019 Behind the Bench Episode 4 - In this episode of Behind the Bench with AJP-Heart and Circ hosted by Lisandra de Castro Bras (East Carolina University) and Jonathan Kirk (Loyola University Chicago), we talk with Charlotte Usselman, Assistant Professor in Kinesiology and Physical Education at McGill University. [ More ] Read the article: 10.1152/ajpheart.00578.2019 Guidelines for Animal Exercise and Training Protocols - What are the best practices for animal models of...